Mild Hyperbaric Oxygen Therapy (mHBOT) has been explored as a potential treatment for children diagnosed with Autism Spectrum Disorder (ASD). Research indicates that a protocol of 40 sessions, typically conducted over a span of 4 to 8 weeks, may yield notable improvements in certain behavioral and cognitive functions.

Research Findings:

• Behavioral Improvements: A multicenter, randomized, double-blind, controlled trial involving children with autism demonstrated significant enhancements in overall functioning, receptive language, social interaction, and eye contact following 40 sessions of mHBOT at 1.3 atmospheres (atm) and 24% oxygen.

  BMC Pediatrics

• Safety Profile: Studies have established the safety of mHBOT in children, even at pressures up to 2.0 atm for 2 hours per day across 40 sessions. The most common side effect observed is middle ear barotrauma, occurring in approximately 2% of patients.

  Vital Kids Medicine

Physiological Mechanisms:

The therapeutic effects of mHBOT in individuals with autism are believed to be associated with several physiological mechanisms:

• Reduction of Neuroinflammation: mHBOT has potent anti-inflammatory effects, which may help alleviate neuroinflammation observed in some individuals with ASD.

  Oxford Academic

• Improvement in Cerebral Hypoperfusion: Many individuals with autism exhibit reduced cerebral blood flow. mHBOT can enhance oxygen delivery to the brain, potentially improving cerebral perfusion.

  BMC Pediatrics

• Oxidative Stress Reduction: Oxidative stress is a common finding in autism. mHBOT may reduce oxidative stress levels, contributing to improved neurological function.

  Oxford Academic

Clinical Observations:

Over the past decade, clinical observations have noted improvements in some patients with autism undergoing mHBOT. These improvements include better social interactions, increased verbal communication, and enhanced cognitive functions. However, it's important to recognize that responses to mHBOT can vary among individuals, and further research is needed to fully understand its efficacy and optimal protocols.

Conclusion:

While mHBOT presents a promising avenue for supporting individuals with autism, it is essential to approach treatment on a case-by-case basis. Consultation with healthcare professionals and consideration of individual medical histories are crucial to determine the appropriateness of mHBOT as a therapeutic option.